Welcome to The Mutlu Lab

The Mutlu Lab’s research is dedicated to understanding the cellular and molecular mechanisms that drive acute lung injury and pulmonary fibrosis. We focus particularly on how macrophage and fibroblast metabolism, specifically mitochondrial metabolic pathways, contribute to the pathogenesis of these diseases.

The Mutlu Lab has extensive expertise in advanced in vitro cell-based methods such as bioenergetics assays and transcriptomics (bulk and single-cell RNA-seq), supported by a dedicated bioinformatics team. We have also established in vivo animal models of acute lung injury (including influenza, LPS exposure, bacterial pneumonia, and particulate matter inhalation) and pulmonary fibrosis (bleomycin). Through these complementary approaches, we aim to uncover pathways that may lead to new therapeutic strategies.